Building on decades of basic research in the biological sciences, new biochemical and cellular mechanisms that lead to disease are being elucidated, with new discoveries reported each week. Concurrently, this understanding renders biology amenable to engineering approaches – how can scientists control, predict and thus design novel ways to circumvent disease?
We develop protein therapeutics and vaccines to address unmet medical needs in infectious diseases. These proteins aim to directly interfere in disease progression or augment essential immune system activities. This work involves design of proteins with therapeutic potential, production in recombinant expression systems, biophysical and biochemical analyses to elucidate the molecular basis of activity and, ultimately, in vitro and in vivo experiments to evaluate a protein's therapeutic potential.