Ellen K. Wagner, Ph.D.

Dissertation:

Engineering and applying next-generation antibody therapeutics for infectious diseases

Education:
The University of Texas at Austin 
       Ph.D. Chemical Engineering (Aug 2012-May 2017)

       NSF Graduate Research Fellowship recipient (2014-2017)

       NSF GROW recipient, Inger Sandlie lab, University of Oslo, Norway (Mar-Oct, 2016)

 

University of Colorado-Boulder
       B.S. Chemical and Biological Engineering with Honors (2011)

 

Winner, Univ Washington Distinguished Young Scholars Seminar 2017 [link] 

       
Publications

Wagner EK, Qerqez AN, Nguyen AW, Maynard JA. Engineering a high affinity TCR-immunoglobulin hybrid therapeutic. In preparation.

 

Wagner EK and Maynard JA. Next generation antibodies to prevent and treat infectious diseases. Current Opinion in ChE, Mar 2018. (invited review) [link]

 

Wagner EK, Wang X, Bui A, Maynard JA. Synergistic neutralization of pertussis toxin by a bispecific antibody in vitro and in vivo. Clinical & Vaccine Immunology, 23 (11): 851-862 (2016). [link]

Nguyen AW, Wagner EK, Posada L, Liu X, Papin JF, Wolf RF, Connelly S, Kaleko M, Maynard JA. Prior exposure to Bordetella species as an excusion criterion in the baboon model of pertussis. J Vet Med Sci, 79 (1): 60-64 (2017).  [link]

Nguyen AW*, Wagner EK*, Laber JR, Goodfield L, Smallridge WE, Harvill ET, Papin JF, Wolf RF, Padlan EA, Bristol A, Kaleko M, Maynard JA. A cocktail of humanized anti-pertussis toxin antibodies limits disease in murine and baboon models of whooping cough. Science Translational Medicine 7 (316): 316ra195 (2015). [link]

*These authors contributed equally.

Kowalsky CA, Faber MS, Nath A, Dann HE, Kelly VW, Liu L, Shanker P, Wagner EK, Maynard JA, Chan C, and Whitehead TA. Rapid fine conformational epitope mapping using comprehensive mutagenesis and deep sequencing. J Biological Chemistry 290 (44): 26457-70 (2015). [link]

Patents

Humanized pertussis antibodies and uses thereof. Maynard JA, Nguyen AW, Wagner EK, Padlan EA. US patent #9,512,204; issued Dec 6, 2016.

 

Bispecific pertussis antibodies. Wagner EK and Maynard JA; Patent application #62/375,344; filed 8/15/2016; PCT filed 8/15/2017.

Email: ellen.wagner AT utexas.edu

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